TIGIT Recombinant Protein, Human, 10ug

The human T-Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) is a recombinant protein consisting of a single glycosylated polypeptide chain with 359 amino acids (22-141aa). T-cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSIG9, VSTM3, WUCAM, V-set is an immune checkpoint, offering potential as an immunotherapeutic target. This transmembrane glycoprotein receptor, featuring an Ig-like V-type and an ITIM in its cytoplasmic region, is expressed on activated and memory T cells, NK cells, and Tregs. Immune checkpoints, known as co-inhibitory receptors, are vital for regulating immune cell function to maintain tolerance and prevent autoimmunity. Established checkpoints like PD-1 and CTLA-4 play significant roles in autoimmune diseases and cancer, with their blockade already approved for cancer therapy. Given the suppressive microenvironments of tumors with elevated immune checkpoints on tumor-infiltrating lymphocytes, targeting TIGIT and similar receptors hold